Commentary: Migrant study designs for epigenetic studies of disease risk.
نویسندگان
چکیده
A molecular epidemiology project on diet and cancer: the EPIC-Italy prospective study. Design and baseline characteristics of participants. Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. Valle C et al. B-vitamins intake, DNA-methylation of one carbon metabolism and homocyst-eine pathway genes and myocardial infarction risk: the EPICOR study. Satellite III non-coding RNAs is a general stress response in human cells. Comparisons of migrant, native and host populations are particularly useful in elucidating the balance between genetic and environmental influences on disease risk. In this issue of IJE, Campanella and colleagues 1 have conducted a novel study of epigenetics in Italian migrants and non-migrants from the European Prospective Investigation
منابع مشابه
Principles of Psychiatric Genetics
Genetic epidemiology The pioneering work of Böök, Sjögren, Angst, Perris, and others in Europe and Kallman, Heston, Rosenthal, Wender, and Kety in the United States firmly established the important role of genetic susceptibility factors in psychiatric disorders. Heston’s [1] original finding that adult offspring of hospitalized schizophrenic mothers had significantly higher rates of schizophren...
متن کاملSystematic review examining differences in HIV, sexually transmitted infections and health-related harms between migrant and non-migrant female sex workers.
OBJECTIVES To assess the evidence of differences in the risk of HIV, sexually transmitted infections (STI) and health-related behaviours between migrant and non-migrant female sex workers (FSWs). METHODS Systematic review of published peer-reviewed articles that reported data on HIV, STIs or health-related harms among migrant compared with non-migrant FSWs. Studies were mapped to describe the...
متن کاملPower and sample size estimation for epigenome-wide association scans to detect differential DNA methylation
BACKGROUND Epigenome-wide association scans (EWAS) are under way for many complex human traits, but EWAS power has not been fully assessed. We investigate power of EWAS to detect differential methylation using case-control and disease-discordant monozygotic (MZ) twin designs with genome-wide DNA methylation arrays. METHODS AND RESULTS We performed simulations to estimate power under the case-...
متن کاملInfluences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia
Recent studies have provided evidence that common genetic variations could account for a proportion of leukemia in adult or children. To evaluate the contribution of candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published studies. The polymorphisms of genes encoding carcinogen-metabolizi...
متن کاملThe Single Nucleotide Polymorphisms in the C-reactive Protein Gene: are they Biomarkers of Cardiovascular Risk?
Recent pre-clinical and clinical studies have revealed the C-reactive protein gene (CRP) is related to the degree of acute rise in plasma C-reactive protein (CRP) levels. Moreover, single nucleotide polymorphisms (SNPs) in the CRP gene could associate with increased risk of cancer, atherosclerosis, diabetes mellitus, bowel disease, rheumatoid arthritis, psoriasis, obstructive pulmonary disease,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- International journal of epidemiology
دوره 46 2 شماره
صفحات -
تاریخ انتشار 2015